Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6310658 | 0.91 | DPP4 (0.44) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL811692 | 0.80 | GABRA1 (0.38) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL2230449 | 0.76 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| Bromide SCHEMBL1907262 | 0.75 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| Bromide SCHEMBL3697387 | 0.75 | DPP4 (0.42) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL819976 | 0.74 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| Hydrochloric Acid SCHEMBL820108 | 0.72 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL13510544 | 0.72 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL13510570 | 0.72 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL13510572 | 0.71 | TSHR (0.43) | GABRA1GABRG2GABRB3GABRB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916893-B2 | Polymerization-active transition metal complexes having bulky ligand systems | SER. V. GMBH (DE) | 2005-07-12 | — | — | US | disclosed |