Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.62 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372555 | 0.86 | HTR1A (0.73) | HTR1AADRA1ACYP3A4CYP2D6HTR2B | |
| SCHEMBL5389828 | 0.86 | HTR1A (0.73) | HTR1AADRA1ACYP3A4CYP2D6HTR2B | |
| Hydrochloric Acid SCHEMBL6435545 | 0.85 | HTR1A (0.72) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL5391694 | 0.85 | HTR1A (0.72) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL5391681 | 0.85 | HTR1A (0.71) | HTR1AADRA1ACYP3A4CYP2D6HTR2B | |
| Oxalic Acid SCHEMBL5377503 | 0.84 | HTR1A (0.71) | HTR1AADRA1ACYP3A4CYP2D6HTR2B | |
| Hydrochloric Acid SCHEMBL6434436 | 0.84 | HTR1A (0.70) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL5375310 | 0.84 | HTR1A (0.70) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL5481090 | 0.83 | HTR1A (0.58) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8651533 | 0.82 | HTR1A (0.57) | HTR1AADRA1ADRD4ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972290-B2 | Piperazine derivatives and their use as anti-inflammatory agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-12-06 | — | — | US | claimed |
| US-20050165025-A1 | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists | RECORDATI IRELAND LTD. (IE) | 2005-07-28 | — | — | US | claimed |
| US-20050165025-A1 | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists | RECORDATI IRELAND LTD. (IE) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165025-A1 | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists | HTR1B, HTR1A, HTR2B | HTR1A 2/4885ADRA1A 32/4885DRD4 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.