Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039437 | 0.85 | HPGD (0.58) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4031705 | 0.83 | SMN1; SMN2 (0.72) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4035684 | 0.78 | SMN1; SMN2 (0.48) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4039252 | 0.78 | SMN1; SMN2 (0.48) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4032891 | 0.78 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4032572 | 0.78 | TSHR (0.58) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4031536 | 0.76 | TSHR (0.58) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL4031280 | 0.76 | TSHR (0.58) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3517537 | 0.76 | NPC1 (0.68) | HPGDSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL4032329 | 0.76 | KMT2A (0.49) | HPGDSMN1; SMN2ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250792-A1 | Substituted piperidine compounds useful as modulators of chemokine receptor activity | MERRILL LYNCH CAPITAL, A DIVISION OF MERRILL LYNCH BUSINESS FINANCIAL SERVICES, INC. AS ADMINISTRATIVE AGENT | 2005-11-10 | — | — | US | disclosed |
| US-6903085-B1 | Substituted piperidine compounds useful as modulators of chemokine receptor activity | ASTRAZENECA, AB (CH) | 2005-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250792-A1 | Substituted piperidine compounds useful as modulators of chemokine receptor activity | CXCR4, CXCR1, CXCR3 | HPGD 1547/4885SMN1; SMN2 3217/4885ALDH1A1 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.