Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543946 | 0.90 | CYP3A4 (0.57) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL6319237 | 0.89 | KMT2A (0.48) | MEN1ALDH1A1KMT2AKCNH2LMNA | |
| SCHEMBL1544043 | 0.83 | MAPT (0.57) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1544141 | 0.82 | LMNA (0.58) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL4944989 | 0.81 | MEN1 (0.50) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1544357 | 0.81 | LMNA (0.49) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1544729 | 0.81 | KMT2A (0.54) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1543757 | 0.81 | POLB (0.55) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1544330 | 0.80 | MAPT (0.50) | MEN1ALDH1A1KMT2AKCNH2MAPT | |
| SCHEMBL1544120 | 0.80 | MAPT (0.50) | MEN1ALDH1A1KMT2AKCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529045-A2 | NEW COMPOUNDS | Astra Zeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004014881-A2 | '1,2,4'OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRA ZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |