Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.49 |
| ▸ | EDNRA | P25101 | 5/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663213 | 0.92 | EDNRB (0.44) | EDNRBEDNRAPTPN1MAPTMIF | |
| SCHEMBL6313751 | 0.86 | EDNRB (0.59) | EDNRBEDNRAPTPN1MAPTLMNA | |
| SCHEMBL6314849 | 0.86 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL6314876 | 0.85 | EDNRB (0.51) | EDNRBEDNRAPTPN1MAPTHTT | |
| SCHEMBL6313623 | 0.78 | EDNRB (0.51) | EDNRBEDNRA | |
| SCHEMBL6314856 | 0.78 | EDNRB (0.52) | EDNRBEDNRALMNATSHR | |
| SCHEMBL6319417 | 0.78 | EDNRB (0.50) | EDNRBEDNRA | |
| SCHEMBL6658446 | 0.77 | EDNRB (0.61) | EDNRBEDNRAMAPTTP53 | |
| SCHEMBL8551759 | 0.74 | EDNRB (0.62) | EDNRBEDNRATP53 | |
| SCHEMBL8546347 | 0.73 | EDNRB (0.66) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | US | claimed |
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | EDNRA, EDNRB, ECE1 | EDNRB 2/4885EDNRA 1/4885PTPN1 3297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.