Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.44 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPRF | P10586 | 1/20 | 0.35 |
| ▸ | PTPRA | P18433 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313613 | 0.92 | EDNRB (0.49) | EDNRBEDNRAPTPN1MAPTMIF | |
| SCHEMBL6658446 | 0.84 | EDNRB (0.61) | EDNRBEDNRAMAPT | |
| SCHEMBL6314876 | 0.78 | EDNRB (0.51) | EDNRBEDNRAPTPN1MAPTPLA2G1B | |
| SCHEMBL6313751 | 0.78 | EDNRB (0.59) | EDNRBEDNRAPTPN1MAPTLMNA | |
| SCHEMBL6314849 | 0.77 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL6313623 | 0.73 | EDNRB (0.51) | EDNRBEDNRAPLA2G1BPLA2G2APLA2G10 | |
| SCHEMBL6319417 | 0.72 | EDNRB (0.50) | EDNRBEDNRAPLA2G1BPLA2G2APLA2G10 | |
| SCHEMBL6314856 | 0.72 | EDNRB (0.52) | EDNRBEDNRAPLA2G1BPLA2G2APLA2G10 | |
| SCHEMBL8551759 | 0.68 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL8546347 | 0.67 | EDNRB (0.66) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441721-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GmbH (DE) | 2004-08-04 | — | — | EP | claimed |
| WO-2003039539-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | claimed |
| WO-1998042709-A1 | ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-10-01 | — | — | WO | claimed |
| EP-1441721-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GmbH (DE) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039539-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | disclosed |