SCHEMBL6313676

SCHEMBL6313676

CCOC(=O)[C@@H]1O[C@@H](O)CS1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPM1B O75688 1/20 0.40
PTPN1 P18031 1/20 0.40
PPP1CC P36873 1/20 0.40
ALDH1A1 P00352 5/20 0.38
TSHR P16473 2/20 0.36
LMNA P02545 2/20 0.33
MAPT P10636 3/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
HSD17B10 Q99714 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
HPGD P15428 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6314340 1.00 PPM1B (0.40) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL6313662 1.00 PPM1B (0.40) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL6314331 1.00 PPM1B (0.40) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL6313666 1.00 PPM1B (0.40) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL7860090 0.81 PPM1B (0.39) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL7867734 0.81 PPM1B (0.39) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL12996745 0.79 PPM1B (0.35) PPM1BPTPN1PPP1CCKDM4EGAA
SCHEMBL12996734 0.79 PPM1B (0.35) PPM1BPTPN1PPP1CCKDM4EGAA
SCHEMBL6313967 0.77 PPM1B (0.36) PPM1BPTPN1PPP1CCALDH1A1TSHR
SCHEMBL6313970 0.77 PPM1B (0.36) PPM1BPTPN1PPP1CCALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6903224-B2 Substituted 1,3-oxathiolanes BIOCHEM PHARMA INC. (CA) 2005-06-07 US claimed
US-20030087918-A1 Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties BIOCHEM PHARMA INC. (CA) 2003-05-08 US claimed
US-20010041797-A1 Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties BIOCHEM PHARMA INC. (CA) 2001-11-15 US claimed
WO-1994014802-A1 PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES BIOCHEM PHARMA INC. (CA) 1994-07-07 WO claimed
US-6903224-B2 Substituted 1,3-oxathiolanes BIOCHEM PHARMA INC. (CA) 2005-06-07 US disclosed
US-20010041797-A1 Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties BIOCHEM PHARMA INC. (CA) 2001-11-15 US disclosed
US-6175008-B1 VIRICIDES FROM REACTION MERCAPTOALDEHYDE WITH ACETOESTER AND 1,4-DITHIANE-2,5-DIOL BIOCHEM PHARMA INC. (CA) 2001-01-16 US disclosed
US-5684164-A CHEMICAL INTERMEDIATES BIOCHEM PHARMA INC. (CA) 1997-11-04 US disclosed
US-5466806-A Processes for preparing substituted 1,3-oxathiolanes with antiviral properties BIOCHEM PHARMA INC. (CA) 1995-11-14 US disclosed
WO-1994014802-A1 PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES BIOCHEM PHARMA INC. (CA) 1994-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030087918-A1 Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties IFNAR1, ZC3HAV1, NUDT1 PPM1B 1226/4885PTPN1 2322/4885PPP1CC 3222/4885
US-20010041797-A1 Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties TYMP, TYMS, PNP PPM1B 1265/4885PTPN1 2413/4885PPP1CC 2223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.