Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | CASR | P41180 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308206 | 0.94 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL6314203 | 0.86 | CASR (0.67) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL6307827 | 0.86 | EGFR (0.58) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL6307712 | 0.83 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL28454350 | 0.82 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL6307024 | 0.81 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL11008746 | 0.79 | CASR (0.72) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL29276532 | 0.79 | CASR (0.72) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL30227085 | 0.79 | CASR (0.72) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA | |
| SCHEMBL6309822 | 0.79 | EGFR (0.74) | ALDH1A1SMN1; SMN2CASRRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |