Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308075 | 0.91 | EGFR (0.49) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6308164 | 0.87 | JAK2 (0.44) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6308557 | 0.84 | NPSR1 (0.52) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6315006 | 0.84 | ATM (0.63) | JAK2JAK1TYK2JAK3ATM | |
| SCHEMBL5877389 | 0.81 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6314177 | 0.80 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6306955 | 0.74 | EGFR (0.72) | RAB9ASMN1; SMN2LMNAMAPTJAK2 | |
| SCHEMBL6308412 | 0.73 | EGFR (0.63) | SMN1; SMN2LMNAMAPTEGFRMEN1 | |
| SCHEMBL6307692 | 0.73 | EGFR (0.69) | SMN1; SMN2LMNAMAPTJAK2JAK1 | |
| SCHEMBL6314793 | 0.73 | MEN1 (0.61) | LMNAMAPTEGFRCHEK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |