Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314668 | 0.84 | NPC1 (0.46) | ATMUSP2POLBJAK2JAK1 | |
| SCHEMBL6308164 | 0.84 | JAK2 (0.44) | ATMUSP2POLBALDH1A1JAK2 | |
| SCHEMBL6308075 | 0.84 | EGFR (0.49) | ATMALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL6308557 | 0.81 | NPSR1 (0.52) | ATMPOLBALDH1A1JAK2JAK1 | |
| SCHEMBL5877284 | 0.79 | ATM (0.58) | ATMUSP2POLBALDH1A1TSHR | |
| SCHEMBL6307822 | 0.78 | ATM (0.57) | ATMUSP2POLBTLR7ALDH1A1 | |
| SCHEMBL6309029 | 0.74 | CASR (0.68) | ALDH1A1KMT2ATSHRGAA | |
| SCHEMBL6314002 | 0.72 | CASR (0.65) | ALDH1A1MEN1KMT2ATSHRGAA | |
| SCHEMBL6309040 | 0.71 | PDE4A (0.56) | POLBMEN1KMT2ATSHRGAA | |
| SCHEMBL3700186 | 0.70 | ATM (0.86) | ATMUSP2POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |