Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CASR | P41180 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | F11 | P03951 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308412 | 0.91 | EGFR (0.63) | EGFRLMNAKDM4EHTTALDH1A1 | |
| SCHEMBL6307813 | 0.91 | EGFR (0.73) | EGFRLMNAKDM4EHTTALDH1A1 | |
| SCHEMBL6306167 | 0.88 | KMT2A (0.63) | EGFRLMNAALDH1A1SMN1; SMN2CASR | |
| SCHEMBL6313940 | 0.88 | EGFR (0.56) | EGFRLMNAKDM4EHTTRXFP1 | |
| SCHEMBL6309029 | 0.88 | CASR (0.68) | EGFRLMNAALDH1A1SMN1; SMN2CASR | |
| SCHEMBL6314890 | 0.87 | EGFR (0.86) | EGFRLMNAALDH1A1SMN1; SMN2CASR | |
| SCHEMBL6306955 | 0.86 | EGFR (0.72) | EGFRLMNAKDM4EHTTALDH1A1 | |
| SCHEMBL6314002 | 0.85 | CASR (0.65) | EGFRLMNAALDH1A1SMN1; SMN2CASR | |
| SCHEMBL6314802 | 0.85 | EGFR (0.83) | EGFRLMNAALDH1A1SMN1; SMN2CASR | |
| SCHEMBL5751134 | 0.85 | CASR (0.77) | EGFRLMNAKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |