Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | F11 | P03951 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309029 | 0.97 | CASR (0.68) | CASRGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6314431 | 0.92 | MEN1 (0.67) | CASRGAAALDH1A1F11MAPT | |
| SCHEMBL6309822 | 0.89 | EGFR (0.74) | CASRGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6307999 | 0.88 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2LMNATSHRF11 | |
| SCHEMBL6314754 | 0.88 | MAPT (0.59) | CASRGAAALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL6308188 | 0.87 | GHSR (0.54) | CASRGAAEGFRF11MAPT | |
| SCHEMBL6306167 | 0.87 | KMT2A (0.63) | CASRGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6314802 | 0.87 | EGFR (0.83) | CASRALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL6309730 | 0.86 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNATSHRF11 | |
| SCHEMBL6394256 | 0.86 | EGFR (0.55) | CASRGAAALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |