Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CASR | P41180 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308903 | 0.91 | CASR (0.57) | EGFRCASRSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6308902 | 0.88 | EGFR (0.64) | EGFRCASRSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6308910 | 0.87 | CASR (0.53) | EGFRCASRSMN1; SMN2MAPTRXRA | |
| SCHEMBL6314890 | 0.84 | EGFR (0.86) | EGFRCASRSMN1; SMN2MAPTTP53 | |
| SCHEMBL6307813 | 0.83 | EGFR (0.73) | EGFRCASRSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6313171 | 0.83 | EGFR (0.69) | EGFRSMN1; SMN2CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL6314802 | 0.82 | EGFR (0.83) | EGFRCASRSMN1; SMN2MAPTTP53 | |
| SCHEMBL6309327 | 0.82 | EGFR (0.51) | EGFRCASRSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6308088 | 0.81 | EGFR (0.70) | EGFRCASRSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6307536 | 0.81 | CASR (0.52) | EGFRCASRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |