Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | CASR | P41180 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313246 | 0.91 | CASR (0.58) | EGFRCASRTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL6314817 | 0.88 | EGFR (0.62) | EGFRCASRTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL6306196 | 0.86 | CASR (0.53) | CASRTP53SMN1; SMN2MAPTMEN1 | |
| SCHEMBL6314890 | 0.85 | EGFR (0.86) | EGFRCASRTP53SMN1; SMN2MAPT | |
| SCHEMBL6314802 | 0.83 | EGFR (0.83) | EGFRCASRTP53SMN1; SMN2MAPT | |
| SCHEMBL6308088 | 0.82 | EGFR (0.70) | EGFRCASRTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL6313293 | 0.82 | CASR (0.52) | EGFRCASR | |
| SCHEMBL6315683 | 0.82 | EGFR (0.69) | EGFRTP53CYP3A4CYP2C19MAPT | |
| SCHEMBL6307813 | 0.82 | EGFR (0.73) | EGFRCASRTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL6313171 | 0.81 | EGFR (0.69) | EGFRTP53SMN1; SMN2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |