⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563242 | 0.79 | IDO1 (0.41) | — | |
| SCHEMBL1560841 | 0.74 | — | — | |
| SCHEMBL1311493 | 0.70 | — | — | |
| SCHEMBL27753471 | 0.70 | — | — | |
| SCHEMBL9563316 | 0.70 | IDO1 (0.52) | — | |
| SCHEMBL31556324 | 0.69 | CYP3A4 (0.44) | — | |
| SCHEMBL27876283 | 0.68 | ALOX5 (0.43) | — | |
| SCHEMBL27597955 | 0.68 | ALOX5 (0.43) | — | |
| SCHEMBL1300584 | 0.65 | — | — | |
| SCHEMBL5101400 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |