Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 20/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724529 | 0.91 | PIK3R1 (0.54) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL632841 | 0.82 | PIK3R1 (0.72) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL893447 | 0.82 | PIK3CA (0.71) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL633055 | 0.80 | PIK3R1 (0.53) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL632497 | 0.80 | PIK3R1 (0.74) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3725448 | 0.79 | PIK3R1 (0.74) | PIK3R1PIK3CAPIK3CD | |
| SCHEMBL631803 | 0.78 | PIK3R1 (0.74) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL633572 | 0.78 | PIK3R1 (0.73) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL633447 | 0.78 | PIK3R1 (0.75) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL634821 | 0.77 | PIK3R1 (1.00) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419429-B1 | IMIDAZOPYRAZINES AS INHIBITORS OF PROTEIN KINASES | CT NAC INVESTIGACIONES ONCOLOGICAS CNIO (ES) | 2014-03-26 | — | — | EP | claimed |
| US-8778935-B2 | Imidazopyrazines for use as kinase inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-07-15 | — | — | US | disclosed |
| WO-2012052745-A1 | COMBINATIONS OF PI3K INHIBITORS WITH A SECOND ANTI -TUMOR AGENT | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |
| EP-2419429-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119264-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCÓLOGICAS (CNIO) (ES) | 2010-10-21 | — | — | WO | disclosed |