Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.62 |
| ▸ | PDE2A | O00408 | 2/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316812 | 1.00 | PDE3B (0.62) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6324397 | 0.79 | PDE3B (0.72) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6317793 | 0.79 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6325720 | 0.79 | PDE3B (0.59) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6320322 | 0.79 | PDE3B (0.72) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6323728 | 0.79 | PDE3B (0.59) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6318287 | 0.78 | PDE3B (0.79) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6325498 | 0.78 | PDE3B (0.65) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6317123 | 0.78 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AMAPT | |
| SCHEMBL6317562 | 0.78 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | disclosed |