Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.74 |
| ▸ | CASP2 | P42575 | 1/20 | 0.57 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961539 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1962966 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1960367 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1958608 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1962964 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1962363 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL3394896 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL6320829 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1961150 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 | |
| SCHEMBL1961327 | 0.98 | MCL1 (0.71) | MCL1CASP2NAAAEPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
| EP-0102062-B1 | 1,3-DITHIANES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1988-11-23 | — | — | EP | disclosed |
| US-4640929-A | Insecticidally, acaricidally, and nematocidally 2-amino-1,3-dithiane derivatives and pesticidal compositions therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-02-03 | — | — | US | disclosed |
| EP-0102062-A2 | 1,3-Dithianes, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | MCL1 584/4885CASP2 1206/4885NAAA 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.