Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318090 | 1.00 | KCNH2 (0.41) | KCNH2OPRM1MEN1CHRM2HTR1A | |
| SCHEMBL6309919 | 0.91 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6309911 | 0.91 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6394116 | 0.91 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6311590 | 0.91 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6311587 | 0.91 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6397911 | 0.90 | TACR1 (0.41) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6312728 | 0.89 | TACR1 (0.40) | KCNH2OPRM1OPRL1TACR1KDM4E | |
| SCHEMBL6397078 | 0.89 | OPRL1 (0.39) | KCNH2OPRM1KMT2AOPRL1TACR1 | |
| SCHEMBL5744911 | 0.89 | TACR1 (0.40) | KCNH2OPRM1OPRL1TACR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | KCNH2 87/4885OPRM1 145/4885MEN1 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.