Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421967 | 0.90 | KDM4E (0.55) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| Cyclopropane SCHEMBL9732364 | 0.83 | KDM4E (0.45) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL2978428 | 0.80 | KDM4E (0.67) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL4962381 | 0.79 | KDM4E (0.48) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL5303665 | 0.79 | KDM4E (0.48) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL7511784 | 0.79 | KDM4E (0.48) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL17242475 | 0.75 | KDM4E (0.60) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL9319718 | 0.73 | KDM4E (0.59) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL10478126 | 0.72 | KDM4E (0.60) | KDM4EKMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL28441880 | 0.72 | KDM4E (0.60) | KDM4EKMT2AHPGDALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |