Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.71 |
| ▸ | PDE2A | O00408 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322954 | 0.88 | PDE3B (0.55) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6318174 | 0.83 | PDE3B (1.00) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6319661 | 0.82 | PDE3B (0.79) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317366 | 0.81 | PDE3B (0.86) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6317888 | 0.80 | PDE3B (0.78) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6324594 | 0.79 | PDE3B (0.81) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6324483 | 0.79 | PDE3B (0.74) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6325710 | 0.79 | PDE3B (0.73) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6323630 | 0.79 | PDE3B (0.73) | PDE3BPDE3APDE2APDE5AALDH1A1 | |
| SCHEMBL6322999 | 0.79 | PDE3B (0.80) | PDE3BPDE3APDE2APDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| US-6887877-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-05-03 | — | — | US | disclosed |
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | disclosed |