SCHEMBL631865

SCHEMBL631865

CC(C(Cl)Br)N1CC(=O)NC1=O

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 3/20 0.45
TOP2B Q02880 3/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CRBN Q96SW2 1/20 0.39
PTGS1 P23219 2/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL630915 0.84 TOP2A (0.48) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL29125125 0.79 TOP2A (0.46) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL7823878 0.79 CRBN (0.39) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL4971941 0.76 TOP2A (0.44) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL16597500 0.74 TOP2A (0.50) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL6312110 0.74 CRBN (0.42) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL10768553 0.73 TOP2A (0.41) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL11086765 0.71 TOP2A (0.46) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL10765254 0.71 TOP2A (0.46) TOP2ATOP2BALDH1A1MAPTTDP1
SCHEMBL27618934 0.71 TOP2A (0.46) TOP2ATOP2BALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2448414-B1 STABILIZED AND ACTIVATED BROMINE SOLUTIONS AS A BIOCIDE AND AS AN ANTIFOULING AGENT BROMINE COMPOUNDS LTD (IL) 2019-04-24 EP claimed
WO-2006026048-A2 BLEACHING WITH IMPROVED WHITENING THE CLOROX COMPANY (US) 2006-03-09 WO claimed
US-20060046946-A1 Adding to wash water a granule or tablet containing a hypohalite-generating compound, a bromide-releasing compound, a fluorescent whitener; increases the measured textile whitening performance versus a control by a Delta W value of greater than 3.0 THE CLOROX COMPANY 2006-03-02 US claimed
US-6982097-B2 Biocidal compositions and methods of using same SANI-CARE SALON PRODUCTS, INC. (US) 2006-01-03 US claimed
US-20050013878-A1 Biocidal compositions and methods of using same SANI-CARE SALON PRODUCTS, INC. 2005-01-20 US claimed
US-5753602-A COMPRISING HALOGEN RELEASE AGENT, ANIONIC SURFACTANT, FILLERS, DISSOLUTION CONTROLLERS THE BLOCK DRUG COMPANY (US) 1998-05-19 US claimed
EP-2865743-B1 Improvements in dispensing devices RECKITT BENCKISER LLC (US) 2024-03-27 EP disclosed
EP-2952570-B1 IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR RECKITT BENCKISER LLC (US) 2021-07-28 EP disclosed
EP-2191077-B1 CAGELESS DISPENSING DEVICE RECKITT BENCKISER LLC (US) 2017-03-15 EP disclosed
EP-3088616-A1 METHOD FOR PRODUCTION OF DISPENSING DEVICES Reckitt Benckiser LLC (US) 2016-11-02 EP disclosed
EP-2310583-B1 DISPENSING DEVICE FOR TOILET BOWL RECKITT BENCKISER LLC (US) 2016-10-05 EP disclosed
US-9334640-B2 Cageless dispensing device RECKITT BENCKISER LLC. (US) 2016-05-10 US disclosed
EP-2952570-A1 IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR Reckitt Benckiser LLC (US) 2015-12-09 EP disclosed
WO-1998026033-A2 CLEANING COMPOSITIONS CONTAINING A HALOGEN BLEACHING AGENT AND A SULFOSUCCINATE SALT LONZA INC. (US) 1998-06-18 WO disclosed
EP-0690674-A4 HALOGEN COMPOSITIONS FOR WATER TREATMENT AND METHOD OF PREPARATION THEREOF GREAT LAKES CHEMICAL CORP (US) 1997-11-19 EP disclosed
US-5641520-A COMPOSITION PREPARED BY ADDING SODIUM HYPOCHLORITE TO AQUEOUS HYDROBROMIC ACID SOLUTION UNTIL COLOR CHANGES FROM ORANGE TO YELLOW, ADDING NON-HALOGENATED 5,5-DIALKYLHYDANTOIN COMPOUND TO SUPPRESS BROMATE ION FORMATION GREAT LAKES CHEMICAL CORPORATION (US) 1997-06-24 US disclosed
EP-0690674-A1 HALOGEN COMPOSITIONS FOR WATER TREATMENT AND METHOD OF PREPARATION THEREOF GREAT LAKES CHEMICAL CORPORATION (US) 1996-01-10 EP disclosed
US-5422126-A Adding sodium hypochlorite to hydrogen bromide solution to yield hypobromous acid, adding dialkylhydantoin to suppress formation of bromate ion GREAT LAKES CHEMICAL CORPORATION (US) 1995-06-06 US disclosed
WO-1994021125-A1 HALOGEN COMPOSITIONS FOR WATER TREATMENT AND METHOD OF PREPARATION THEREOF GREAT LAKES CHEMICAL CORPORATION (US) 1994-09-29 WO disclosed
US-4537697-A Method of enhancing solubility of halogenated hydantoins GLYCO, INC. (US) 1985-08-27 US disclosed