Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.63 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | TEK | Q02763 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311579 | 0.76 | AURKA (0.73) | IGF1RINSRKDREGFRMET | |
| SCHEMBL6320480 | 0.75 | IGF1R (0.69) | IGF1RINSRKDREGFRMET | |
| SCHEMBL31378824 | 0.75 | IGF1R (0.82) | IGF1RINSRKDREGFRMET | |
| SCHEMBL6314276 | 0.75 | IGF1R (0.66) | IGF1RINSRKDREGFRMET | |
| SCHEMBL31592443 | 0.74 | IGF1R (0.65) | IGF1RINSRKDREGFRMET | |
| SCHEMBL6312556 | 0.74 | IGF1R (0.69) | IGF1RINSRKDREGFRMET | |
| SCHEMBL1926077 | 0.73 | PLK1 (0.68) | KDRMETCDK2KMT2AFLT4 | |
| SCHEMBL6319730 | 0.73 | IGF1R (0.71) | IGF1RINSRKDREGFRMET | |
| SCHEMBL6642791 | 0.73 | IGF1R (0.71) | IGF1RINSRKDREGFRMET | |
| SCHEMBL6319666 | 0.73 | IGF1R (0.72) | IGF1RINSRKDREGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |