Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.54 |
| ▸ | GLP1R | P43220 | 7/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703222 | 0.91 | TACR1 (0.57) | TACR1GLP1RKMT2A | |
| SCHEMBL4521193 | 0.89 | TACR1 (0.53) | TACR1GLP1RPTPN1KMT2A | |
| SCHEMBL4698287 | 0.85 | TACR1 (0.63) | TACR1MAPK1KMT2A | |
| SCHEMBL4699883 | 0.84 | MCL1 (0.41) | TACR1PTPN1MAPK1KMT2AHDAC8 | |
| SCHEMBL6318956 | 0.83 | TACR1 (0.54) | TACR1 | |
| SCHEMBL4699880 | 0.83 | MAPK1 (0.44) | MAPK1KMT2AHDAC8 | |
| SCHEMBL4698359 | 0.83 | MCL1 (0.41) | TACR1MAPK1KMT2A | |
| SCHEMBL4701927 | 0.83 | MC4R (0.43) | MAPK1KMT2A | |
| SCHEMBL4701772 | 0.83 | MC4R (0.45) | MAPK1KMT2A | |
| SCHEMBL4699046 | 0.82 | MAPK1 (0.43) | PTPN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977264-B2 | Substituted piperidines and methods of use | AMGEN INC. (US) | 2005-12-20 | — | — | US | disclosed |