Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 12/20 | 0.90 |
| ▸ | P2RY6 | Q15077 | 10/20 | 0.90 |
| ▸ | P2RY4 | P51582 | 7/20 | 0.90 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2349022 | 1.00 | P2RY2 (0.90) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL17972335 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL3503025 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL21418853 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL14765539 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL625973 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| Triphosphate SCHEMBL17894276 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL21418854 | 0.98 | P2RY2 (0.94) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL1402562 | 0.91 | P2RY2 (0.82) | P2RY2P2RY6P2RY4P2RY14 | |
| SCHEMBL1402556 | 0.91 | P2RY2 (0.82) | P2RY2P2RY6P2RY4P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977246-B2 | Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-6916613-B2 | Compositions, methods, kits and apparatus for determining the presence or absence of target molecules | Q-RNA, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-20030180725-A1 | Compositions, methods, kits and apparatus for determining the presence or absence of target molecules | Q-RNA, INC. | 2003-09-25 | — | — | US | disclosed |
| US-20020082417-A1 | Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency | MERCK SHARP & DOHME CORP. | 2002-06-27 | — | — | US | disclosed |
| US-6348589-B1 | INCREASE THE HYDRATION OF RETAINED MUCUS SECRETIONS, STIMULATE THE PRODUCTION OF MUCINS; TREATING CHRONIC BRONCHITIS, CYSTIC FIBROSIS AND PNEUMONIA | INSPIRE PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6225058-B1 | MIXING PAIRED RNA OF DEFINED NUCLEOTIDE SEQUENCES WITH SAMPLE, ALLOWING BINDING OF RNA WITH SAMPLE TO FORM COMPLEX, USING RNA REPLICASE TO PRODUCE RNA, MONITORING FOR NEW RNA AS INDICATION OF TARGET MOLECULE | INVITRO DIAGNOSTICS, INC. | 2001-05-01 | — | — | US | disclosed |
| EP-0981534-A2 | DINUCLEOTIDES AND THEIR USES | Inspire Pharmaceuticals, Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| US-5837861-A | RESPIRATORY SYSTEM DISORDERS, BRONCHITIS AND CYSTIC FIBROSIS | INSPIRE PHARMACEUTICALS, INC. (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1998034942-A2 | DINUCLEOTIDES AND THEIR USE | INSPIRE PHARMACEUTICALS, INC. (US) | 1998-08-13 | — | — | WO | disclosed |
| US-4749647-A | Polymerization-induced separation assay using recognition pairs | GENETIC SYSTEMS CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082417-A1 | Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency | P2RY4, P2RY2, P2RY1 | P2RY2 2/4885P2RY6 4/4885P2RY4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.