Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329837 | 0.95 | KDR (0.42) | KDRPDGFRBKITL3MBTL1L3MBTL3 | |
| SCHEMBL6323517 | 0.91 | L3MBTL3 (0.47) | KDRPDGFRBKITL3MBTL1L3MBTL3 | |
| SCHEMBL6327802 | 0.89 | KDR (0.43) | KDRPDGFRBKITL3MBTL1L3MBTL3 | |
| SCHEMBL6322401 | 0.89 | KDR (0.40) | KDRPDGFRBKITL3MBTL1L3MBTL3 | |
| SCHEMBL6766682 | 0.87 | KDR (0.37) | KDRPDGFRBKITL3MBTL1L3MBTL3 | |
| SCHEMBL6321738 | 0.87 | TLR9 (0.42) | KDRPDGFRBL3MBTL1L3MBTL3CDK5 | |
| SCHEMBL6321376 | 0.86 | CYP2D6 (0.40) | KDRL3MBTL1L3MBTL3CDK5CDK5R1 | |
| SCHEMBL6327898 | 0.84 | KDR (0.38) | KDRPDGFRBKITMEN1KMT2A | |
| SCHEMBL6327922 | 0.83 | ALK (0.40) | KDRPDGFRBKITMEN1KMT2A | |
| SCHEMBL6322518 | 0.83 | FLT1 (0.41) | KDRPDGFRBKITMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | KDR 819/4885PDGFRB 575/4885KIT 972/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | KDR 819/4885PDGFRB 575/4885KIT 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.