Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.56 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29680396 | 1.00 | TRPM4 (0.56) | TRPM4PTPN22NQO2PTPN1CYP1A2 | |
| SCHEMBL31258857 | 0.84 | TRPM4 (0.58) | TRPM4PTPN22NQO2PTPN1CYP1A2 | |
| SCHEMBL4247740 | 0.83 | PTPN22 (0.45) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL30151482 | 0.79 | TRPM4 (0.62) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL27738 | 0.79 | TRPM4 (0.62) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL28159001 | 0.79 | TRPM4 (0.62) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL11298208 | 0.79 | PTPN22 (0.42) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL29344183 | 0.79 | CYP1A2 (0.45) | TRPM4PTPN22NQO2CYP1A2CASP6 | |
| SCHEMBL24857744 | 0.79 | TRPM4 (0.52) | TRPM4PTPN22NQO2PTPN1CYP1A2 | |
| SCHEMBL16646896 | 0.79 | TRPM4 (0.52) | TRPM4PTPN22NQO2PTPN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388606-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2025-12-25 | — | — | US | disclosed |
| US-12398154-B2 | Azaquinazoline pan-KRas inhibitors | Mirati Therapeutics, Inc. (US) | 2025-08-26 | — | — | US | disclosed |
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116829151-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| US-20230072276-A1 | Azaquinazoline pan-KRas inhibitors | Mirati Therapeutics, Inc. | 2023-03-09 | — | — | US | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| EP-1441011-B1 | Energy transfer dye containing an aromatic-substituted xanthene dye as donor dye and/or acceptor dye | LIFE TECHNOLOGIES CORP (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-1441011-B1 | Energy transfer dye containing an aromatic-substituted xanthene dye as donor dye and/or acceptor dye | LIFE TECHNOLOGIES CORP (US) | 2012-02-22 | — | — | EP | disclosed |
| US-RE39663-E1 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes | APPLERA CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| WO-2001057264-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6221604-B1 | CONJUGATED TO SUBSTRATES SUCH AS NUCLEOSIDES OR NUCLEOTIDES AND USED AS DETECTION LABELS IN MOLECULAR BIOLOGY EXPERIMENTS; ENERGY TRANSFER DYE | PE CORPORATION | 2001-04-24 | — | — | US | disclosed |
| EP-1019453-A1 | AROMATIC-SUBSTITUTED XANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 2000-07-19 | — | — | EP | disclosed |
| US-6020481-A | FLUORESCENT LABELING REAGENTS; DIDEOXY POLYNUCLEOTIDE SEQUENCING AND FRAGMENT ANALYSIS METHODS. | THE PERKIN-ELMER CORPORATION (US) | 2000-02-01 | — | — | US | disclosed |
| US-6008379-A | USEFUL AS FLUORESCENT DYES FOR LABELING | THE PERKIN-ELMER CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0891393-B1 | ASYMMETRIC BENZOXANTHENE DYES | PERKIN ELMER CORP (US) | 1999-06-30 | — | — | EP | disclosed |
| WO-1999016832-A1 | AROMATIC-SUBSTITUTED XANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1999-04-08 | — | — | WO | disclosed |
| EP-0891393-A1 | ASYMMETRIC BENZOXANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5840999-A | NAPHTHOL INTERMEDIATES FOR FLUORESCENT DYES | THE PERKIN-ELMER CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1997036960-A1 | ASYMMETRIC BENZOXANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230072276-A1 | Azaquinazoline pan-KRas inhibitors | KRAS, NRAS, HRAS | TRPM4 4586/4885PTPN22 1891/4885NQO2 487/4885 |
| US-12398154-B2 | Azaquinazoline pan-KRas inhibitors | KRAS, NRAS, HRAS | TRPM4 4586/4885PTPN22 1891/4885NQO2 487/4885 |
| US-20250388606-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | KRAS, NRAS, HRAS | TRPM4 4527/4885PTPN22 1285/4885NQO2 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.