Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 9/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | FLT1 | P17948 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.44 |
| ▸ | STK3 | Q13188 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321750 | 0.99 | KDR (0.53) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6321746 | 0.93 | KDR (0.55) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6323841 | 0.88 | PDGFRB (0.57) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6329410 | 0.86 | PDGFRB (0.49) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6328524 | 0.84 | KDR (0.66) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6323543 | 0.83 | KDR (0.46) | KDRPDGFRBFGFR1PDGFRAEGFR | |
| SCHEMBL6327103 | 0.82 | KDR (0.58) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6320045 | 0.81 | KDR (0.54) | KDRPDGFRBFGFR1PDGFRAEGFR | |
| SCHEMBL6319421 | 0.80 | KDR (0.49) | KDRPDGFRBFGFR1TLK2PDGFRA | |
| SCHEMBL6330051 | 0.79 | KDR (0.48) | KDRPDGFRBFGFR1TLK2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |