Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | RET | P07949 | 4/20 | 0.47 |
| ▸ | MET | P08581 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.47 |
| ▸ | STK3 | Q13188 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330051 | 0.91 | KDR (0.48) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6323877 | 0.88 | KDR (0.44) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6322851 | 0.87 | KDR (0.46) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6323956 | 0.86 | MET (0.54) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6323947 | 0.86 | MET (0.54) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6327454 | 0.85 | FLT1 (0.47) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6321750 | 0.82 | KDR (0.53) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6328014 | 0.82 | KDR (0.54) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6320259 | 0.81 | KDR (0.52) | KDRFGFR1PDGFRBFLT3ALK | |
| SCHEMBL6319421 | 0.81 | KDR (0.49) | KDRFGFR1PDGFRBFLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | CDK1, CDK2, CDK3 | KDR 448/4885FGFR1 218/4885PDGFRB 1015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.