Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 19/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634821 | 0.93 | PIK3R1 (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL632355 | 0.89 | PIK3CA (1.00) | PIK3CAPIK3R1 | |
| SCHEMBL633173 | 0.89 | PIK3R1 (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL20458896 | 0.89 | PIK3R1 (0.80) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL15603041 | 0.88 | PIK3R1 (0.85) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL15603053 | 0.88 | PIK3R1 (0.83) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL633032 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL633212 | 0.85 | PIK3R1 (0.79) | PIK3CAPIK3R1 | |
| SCHEMBL2730144 | 0.84 | PIK3R1 (0.72) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL632562 | 0.83 | PIK3CA (1.00) | PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419429-B1 | IMIDAZOPYRAZINES AS INHIBITORS OF PROTEIN KINASES | CT NAC INVESTIGACIONES ONCOLOGICAS CNIO (ES) | 2014-03-26 | — | — | EP | claimed |
| US-8778935-B2 | Imidazopyrazines for use as kinase inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-07-15 | — | — | US | disclosed |
| EP-2419429-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119264-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCÓLOGICAS (CNIO) (ES) | 2010-10-21 | — | — | WO | disclosed |