Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559549 | 0.76 | KMT2A (0.41) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL18284663 | 0.74 | SIGMAR1 (0.45) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL4557805 | 0.72 | SIGMAR1 (0.42) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL11757825 | 0.71 | SIGMAR1 (0.41) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL9530943 | 0.71 | SIGMAR1 (0.46) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL569963 | 0.70 | SIGMAR1 (0.48) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| Succinic Acid SCHEMBL1360757 | 0.70 | SIGMAR1 (0.44) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL4559545 | 0.70 | SIGMAR1 (0.44) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| Succinic Acid SCHEMBL19644019 | 0.70 | SIGMAR1 (0.44) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3256689 | 0.70 | SIGMAR1 (0.41) | SIGMAR1CHRM2CHRM1CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419413-A1 | DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119992-A1 | DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-21 | — | — | WO | disclosed |