Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320777 | 0.88 | ALDH1A1 (0.48) | POLBKMT2AMEN1ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7673032 | 0.73 | SMN1; SMN2 (0.31) | KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL6326444 | 0.73 | CHEK1 (0.34) | SIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5203080 | 0.72 | SLC18A2 (0.32) | KMT2AMEN1KDM4E | |
| SCHEMBL28219784 | 0.71 | POLB (0.67) | PDCD1CD274POLBKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7675998 | 0.71 | KMT2A (0.34) | KMT2AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL6321579 | 0.71 | ZAP70 (0.31) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6319371 | 0.70 | MAP3K11 (0.30) | — | |
| SCHEMBL7461309 | 0.67 | PDCD1 (0.63) | PDCD1CD274POLBKMT2AMEN1 | |
| SCHEMBL3271717 | 0.66 | ALDH1A1 (0.52) | PDCD1CD274NEK2PLK1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176764-A1 | Medicine for treating cancer | KOWA CO., LTD (JP) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176764-A1 | Medicine for treating cancer | HDAC4, HDAC3, NR4A3 | PDCD1 4542/4885CD274 3848/4885NEK2 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.