Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SENP5 | Q96HI0 | 5/20 | 0.40 |
| ▸ | SENP2 | Q9HC62 | 5/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320201 | 1.00 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2SENP5SENP2SENP1 | |
| SCHEMBL6318500 | 0.92 | EGFR (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6318492 | 0.92 | EGFR (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6322269 | 0.89 | PDPK1 (0.43) | ALDH1A1SMN1; SMN2SENP5SENP2SENP1 | |
| SCHEMBL6319709 | 0.89 | PDPK1 (0.43) | ALDH1A1SMN1; SMN2SENP5SENP2SENP1 | |
| Hydrochloric Acid SCHEMBL6327173 | 0.89 | AKT2 (0.44) | ALDH1A1SMN1; SMN2SENP5SENP2SENP1 | |
| Hydrochloric Acid SCHEMBL6327176 | 0.89 | AKT2 (0.44) | ALDH1A1SMN1; SMN2SENP5SENP2SENP1 | |
| SCHEMBL6320720 | 0.88 | EGFR (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6320290 | 0.88 | EGFR (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6320358 | 0.87 | EGFR (0.44) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-03-25 | — | — | US | disclosed |
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | CDK1, CDK2, CDK3 | ALDH1A1 1810/4885SMN1; SMN2 4425/4885SENP5 2893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.