⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321755 | 0.76 | — | — | |
| SCHEMBL11230182 | 0.74 | CYP3A4 (0.42) | — | |
| SCHEMBL190317 | 0.73 | — | — | |
| SCHEMBL908315 | 0.73 | — | — | |
| SCHEMBL12968317 | 0.73 | — | — | |
| SCHEMBL28729572 | 0.71 | CYP3A4 (0.43) | — | |
| SCHEMBL3723702 | 0.68 | BACE1 (0.44) | — | |
| SCHEMBL3724189 | 0.68 | CYP3A4 (0.45) | — | |
| SCHEMBL12192591 | 0.68 | CYP3A4 (0.41) | — | |
| SCHEMBL21597387 | 0.68 | KDM4E (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912734-B2 | Solid-phase synthesis of oligonucleotides containing N6-(2-deoxy-alpha,beta-derythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy⋅dG) | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | disclosed |
| US-20210238213-A1 | SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING N6-(2-DEOXY-ALPHA,BETA-DERYTHROPENTOFURANOSYL)-2,6-DIAMINO-4-HYDROXY-5-FORMAMIDOPYRIMIDINE (Fapy.dG) | THE JOHNS HOPKINS UNIVERSITY | 2021-08-05 | — | — | US | disclosed |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| WO-2011035009-A1 | HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN | HERCULES TECHNOLOGY MANAGEMENT CO V, INC. (US) | 2011-03-24 | — | — | WO | disclosed |
| US-6870053-B2 | Chloropyrimidine intermediates | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-22 | — | — | US | disclosed |
| US-20030187263-A1 | Chloropvrimidine intermediates | SMITHKLINE BEECHAM CORPORATION | 2003-10-02 | — | — | US | disclosed |
| US-6555687-B1 | N,N'-(4,6-dichloro-2,5-pyrimidinediyl)bisformamide as a chemical intermediate for 9-substituted-2-aminopurines, such as famciclovir and penciclovir; viricides; HIV and hepatitus virus | SMITHKLINE BEECHAM CORPORATION | 2003-04-29 | — | — | US | disclosed |
| US-6552193-B1 | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | disclosed |
| US-20020173649-A1 | Chloropvrimidine intermediates | SMITHKLINE BEECHAM CORPORATION | 2002-11-21 | — | — | US | disclosed |
| US-6087501-A | Chloropyrimidine intermediates and processes for their preparation | GLAXO WELLCOME INC. (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0741710-B1 | CHLOROPYRIMIDINE INTERMEDIATES | WELLCOME FOUND (GB) | 2000-05-10 | — | — | EP | disclosed |
| US-5917042-A | Process for the preparation of 2,5-diamino-4,6-dichloropyrimidine | GLAXO WELLCOME INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5917041-A | Chloropyrimidine intermediates | GLAXO WELLCOME INC. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0741710-A1 | CHLOROPYRIMIDE INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021161-A1 | CHLOROPYRIMIDE INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |