Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.48 |
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323951 | 1.00 | FLT3 (0.49) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6321383 | 0.91 | FLT3 (0.55) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6321388 | 0.91 | FLT3 (0.55) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6324302 | 0.89 | KDR (0.56) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6324306 | 0.89 | KDR (0.56) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL16090377 | 0.88 | MET (0.54) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6323692 | 0.88 | MET (0.56) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6323687 | 0.88 | MET (0.56) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6320750 | 0.87 | KDR (0.57) | FLT3AURKBKDRFGFR1MET | |
| SCHEMBL6320753 | 0.87 | KDR (0.57) | FLT3AURKBKDRFGFR1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | claimed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | claimed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | claimed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | claimed |
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | FLT3 596/4885AURKB 325/4885KDR 819/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | FLT3 596/4885AURKB 325/4885KDR 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.