Histidine

Histidine

SCHEMBL6324014

N[C@@H](Cc1c[nH]cn1)C(=O)O.O=P(O)(O)OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNPH1 O43598 10/20 0.59
P2RY1 P47900 4/20 0.59
P2RY2 P41231 3/20 0.59
SRC P12931 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
PRKAB2 O43741 1/20 0.59
TRPM2 O94759 1/20 0.59
LDHA P00338 1/20 0.59
ADRB2 P07550 1/20 0.59
FBP1 P09467 1/20 0.59
ADORA1 P30542 1/20 0.59
PRKAG1 P54619 1/20 0.59
PRKAA2 P54646 1/20 0.59
PDE4D Q08499 1/20 0.59
KCNH2 Q12809 1/20 0.59
PRKAA1 Q13131 1/20 0.59
PDE3A Q14432 1/20 0.59
TAS1R3 Q7RTX0 1/20 0.59
TAS1R1 Q7RTX1 1/20 0.59
P2RY11 Q96G91 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4314075 0.87 P2RY12 (0.61) DNPH1P2RY1P2RY2SRCSMN1; SMN2
Glutamic Acid SCHEMBL30621216 0.84 DNPH1 (0.65) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL11645423 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL16141757 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL29775236 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL24145247 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL25168081 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL161318 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL19255 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2
SCHEMBL29358651 0.83 DNPH1 (0.79) DNPH1P2RY1P2RY2SRCSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6858244-B2 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2005-02-22 US claimed
US-20030198723-A1 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2003-10-23 US claimed
US-6858244-B2 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2005-02-22 US disclosed
US-20030198723-A1 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2003-10-23 US disclosed
EP-1277413-A1 SEASONING COMPOSITIONS, FOODS AND DRINKS WITH THE USE THEREOF AND PROCESS FOR PRODUCING THE SAME Ajinomoto Co., Inc. (JP) 2003-01-22 EP disclosed