Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | RECQL | P46063 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALPL | P05186 | 1/20 | 0.67 |
| ▸ | ALPI | P09923 | 1/20 | 0.67 |
| ▸ | ALPG | P10696 | 1/20 | 0.67 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.67 |
| ▸ | CASP6 | P55212 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 9/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Acetylaminorhodanine SCHEMBL8000045 | 0.77 | MAPT (0.73) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL8224178 | 0.77 | MAPT (0.58) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL2098652 | 0.76 | MAPT (0.56) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL43968 | 0.74 | MAPT (0.68) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL10278696 | 0.73 | MAPT (0.67) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL10278642 | 0.73 | MAPT (0.77) | MAPTALDH1A1RECQLPOLBTDP1 | |
| N-Benzoylaminorhodanine SCHEMBL8595198 | 0.70 | MAPT (0.74) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL39550 | 0.69 | MAPT (0.55) | MAPTALDH1A1RECQLPOLBTDP1 | |
| SCHEMBL11985604 | 0.69 | — | — | |
| SCHEMBL8356860 | 0.68 | MAPT (1.00) | MAPTALDH1A1RECQLPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050118664-A1 | Fluorogenic protease substrates | BLACKMAN MICHAEL J (GB) | 2005-06-02 | — | — | US | disclosed |
| EP-1472284-A2 | FLUOROGENIC PROTEASE SUBSTRATES DOUBLY LABELLED WITH RHODAMINE MOIETIES | Medical Research Council (GB) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003057723-A2 | FLUOROGENIC PROTEASE SUBSTRATES DOUBLY LABELLED WITH RHODAMINE MOIETIES | MEDICAL RESEARCH COUNCIL (GB) | 2003-07-17 | — | — | WO | disclosed |