Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204166 | 0.84 | MAPT (0.59) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL1749545 | 0.84 | MAPT (0.59) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL1749546 | 0.84 | MAPT (0.59) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL1749644 | 0.83 | MAPT (0.57) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL1749646 | 0.83 | MAPT (0.57) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL3551387 | 0.83 | MAPT (0.57) | MAPTALDH1A1ALOX12HTTCA12 | |
| SCHEMBL2126747 | 0.82 | MAPT (0.40) | MAPTALDH1A1HTTMAPK1POLB | |
| Hydrochloric Acid SCHEMBL5201475 | 0.82 | MAPT (0.56) | MAPTALDH1A1ALOX12HTTCA12 | |
| Hydrochloric Acid SCHEMBL4626118 | 0.81 | MAPT (0.42) | MAPTALDH1A1HTTMAPK1POLB | |
| Hydrochloric Acid SCHEMBL2128388 | 0.81 | MAPT (0.42) | MAPTALDH1A1HTTMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946005-B2 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-09-20 | — | — | US | disclosed |
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-10-07 | — | — | US | disclosed |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | SABELLE STEPHANE (FR) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | MAPT 903/4885ALDH1A1 2448/4885ALOX12 4589/4885 |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | MAPT 903/4885ALDH1A1 2448/4885ALOX12 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.