Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633221 | 0.90 | CCR2 (0.46) | CCR2KCNH2 | |
| SCHEMBL632814 | 0.89 | CCR2 (0.47) | CCR2KCNH2 | |
| SCHEMBL631721 | 0.89 | CCR2 (0.46) | CCR2KCNH2 | |
| SCHEMBL632445 | 0.87 | CCR2 (0.50) | CCR2KCNH2 | |
| SCHEMBL632467 | 0.86 | TRPV1 (0.45) | CCR2KCNH2 | |
| SCHEMBL631768 | 0.84 | CCR2 (0.45) | CCR2KCNH2 | |
| SCHEMBL632403 | 0.84 | CCR2 (0.43) | CCR2KCNH2 | |
| SCHEMBL632015 | 0.81 | CCR2 (0.41) | CCR2KCNH2CYP2D6 | |
| SCHEMBL632479 | 0.81 | CCR2 (0.41) | CCR2KCNH2CYP2D6 | |
| SCHEMBL629391 | 0.81 | CCR2 (0.48) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419418-A1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | Janssen Pharmaceutica, N.V. (BE) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010121036-A1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-21 | — | — | WO | disclosed |