Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108942 | 0.98 | ALDH1A1 (0.36) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL27541297 | 0.94 | ALDH1A1 (0.34) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| Ethane SCHEMBL17593441 | 0.94 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL2511955 | 0.94 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL1007938 | 0.94 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL3294493 | 0.94 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL27719314 | 0.92 | HSD17B10 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| Hydrochloric Acid SCHEMBL28378505 | 0.92 | SMN1; SMN2 (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL28248770 | 0.92 | POLB (0.37) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL28790654 | 0.90 | POLB (0.38) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419425-A1 | IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE | AstraZeneca AB (SE) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120237-A1 | IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-10-21 | — | — | WO | disclosed |