Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359507 | 0.94 | KDM4E (0.65) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8437113 | 0.85 | KDM4E (0.71) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL6360338 | 0.84 | MAPT (0.67) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL13316205 | 0.83 | GAA (0.53) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL24590212 | 0.83 | MAPT (0.65) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL7799270 | 0.80 | KDM4E (0.69) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL13316204 | 0.79 | MEN1 (0.60) | KDM4EGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL6361446 | 0.78 | GAA (0.73) | GAASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL6437787 | 0.77 | L3MBTL1 (0.61) | KDM4EGAASMN1; SMN2RECQLMEN1 | |
| SCHEMBL6360344 | 0.77 | NPC1 (0.75) | KDM4ESMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601674-A2 | HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO 4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004022558-A2 | HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-03-18 | — | — | WO | disclosed |