Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | GOT1 | P17174 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094630 | 0.82 | MAPK14 (0.52) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL5276413 | 0.81 | MAPK14 (0.53) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL6096876 | 0.80 | MAPK14 (0.51) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL5925678 | 0.79 | MAPK14 (0.51) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL3210544 | 0.77 | MAPK14 (0.65) | MAPK14GAAMAPTMGLLCCR5 | |
| SCHEMBL6112304 | 0.73 | MAPK14 (0.67) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL16598948 | 0.73 | MAPK14 (0.64) | MAPK14MAPTMGLLCCR5HTT | |
| SCHEMBL6095813 | 0.72 | MAPK14 (0.57) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL2216397 | 0.71 | MAPK14 (0.64) | MAPK14GAAMAPTCCR3MGLL | |
| SCHEMBL6097059 | 0.70 | MAPK14 (0.57) | MAPK14GAAMAPTCCR3MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | disclosed |