Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | PRKCB | P05771 | 11/20 | 0.51 |
| ▸ | PRKCA | P17252 | 9/20 | 0.51 |
| ▸ | PRKCH | P24723 | 9/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.51 |
| ▸ | PRKACA | P17612 | 5/20 | 0.51 |
| ▸ | PRKACG | P22612 | 5/20 | 0.51 |
| ▸ | PRKACB | P22694 | 5/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | PRKCG | P05129 | 3/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335215 | 0.88 | GSK3B (0.52) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL6324887 | 0.88 | PRKCB (0.51) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL6328464 | 0.88 | PRKD1 (0.52) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL224940 | 0.87 | CDK4 (0.61) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL6329959 | 0.84 | CDK4 (0.60) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL2881681 | 0.80 | CDK4 (0.54) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL2343710 | 0.80 | CDK4 (0.63) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL3052915 | 0.80 | CDK4 (0.48) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL3047624 | 0.78 | OPA1 (0.51) | CDK4CCND1PRKCBPRKCAPRKCH | |
| SCHEMBL6330146 | 0.78 | PRKACA (0.53) | CDK4CCND1PRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867198-B2 | Agents and methods for the treatment of proliferative diseases | ELI LILLY AND COMPANY (US) | 2005-03-15 | — | — | US | disclosed |
| US-20030229026-A1 | Agents and methods for the treatment of proliferative diseases | ELI LILLY AND COMPANY | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229026-A1 | Agents and methods for the treatment of proliferative diseases | MKI67, CDKN1A, CDK1 | CDK4 5/4885CCND1 70/4885PRKCB 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.