Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328132 | 0.90 | NR1H2 (0.37) | NR1H2FKBP1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6335382 | 0.89 | CYP3A4 (0.38) | CYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL6326977 | 0.89 | CYP3A4 (0.38) | CYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL5595735 | 0.89 | CYP3A4 (0.38) | CYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL6329218 | 0.87 | CYP3A4 (0.41) | CYP3A4KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13390583 | 0.84 | CYP3A4 (0.42) | NR1H2CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL3306909 | 0.84 | CYP3A4 (0.42) | NR1H2CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL14187650 | 0.84 | CYP3A4 (0.42) | NR1H2CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL9635522 | 0.81 | POLB (0.50) | NR1H2CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL116396 | 0.81 | POLB (0.50) | NR1H2CYP3A4CYP1A2POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953805-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-10-11 | — | — | US | disclosed |
| US-20050170999-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | FILLA SANDRA A (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050170999-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | SLC1A2, SLC1A1, SLC1A3 | NR1H2 863/4885CYP3A4 3320/4885CYP1A2 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.