Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 13/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.73 |
| ▸ | HRH1 | P35367 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL6325016 | 0.86 | CYP2J2 (0.77) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11793534 | 0.86 | CYP2J2 (1.00) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL11795603 | 0.85 | CYP2J2 (0.98) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL27627976 | 0.85 | CYP2J2 (0.74) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Methane SCHEMBL6332223 | 0.84 | HRH1 (0.66) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL48803 | 0.84 | CYP2J2 (0.75) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL12139245 | 0.84 | CYP2J2 (1.00) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL2235075 | 0.83 | CYP2J2 (0.74) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL11791455 | 0.83 | CYP2J2 (0.98) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11798280 | 0.83 | CYP2J2 (0.84) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. | 2004-08-26 | — | — | US | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | LING KAH HIING (US) | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | CYP2J2 277/4885CYP3A4 161/4885CYP2C9 1238/4885 |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | HRH4, HRH2, HRH1 | CYP2J2 252/4885CYP3A4 149/4885CYP2C9 426/4885 |
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | CYP2J2 277/4885CYP3A4 161/4885CYP2C9 1238/4885 |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | CYP2J2 258/4885CYP3A4 140/4885CYP2C9 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.