Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 1.00 |
| ▸ | HTR2B | P41595 | 12/20 | 1.00 |
| ▸ | HTR2A | P28223 | 11/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905999 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| SCHEMBL4829208 | 0.92 | HTR2C (1.00) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL4824843 | 0.90 | HTR2A (0.80) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL4824850 | 0.90 | HTR2A (0.80) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| SCHEMBL4830519 | 0.84 | HTR2A (0.72) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| SCHEMBL14280400 | 0.83 | HTR2C (0.71) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL4822644 | 0.83 | HTR2C (0.81) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL4822638 | 0.83 | HTR2C (0.81) | HTR2CHTR2BHTR2ACYP1A2CYP3A4 | |
| SCHEMBL25882779 | 0.81 | HTR2C (0.68) | HTR2CHTR2BHTR2ALMNA | |
| SCHEMBL8888063 | 0.79 | HTR2C (0.65) | HTR2CHTR2BHTR2AHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962939-B1 | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands | VERNALIS RESEARCH LIMITED (GB) | 2005-11-08 | — | — | US | disclosed |