Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.65 |
| ▸ | HTR2A | P28223 | 10/20 | 0.65 |
| ▸ | HTR2B | P41595 | 6/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499133 | 0.92 | HTR2A (0.62) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL8888882 | 0.92 | HTR2C (0.67) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| Ammonia Solution, Strong SCHEMBL906002 | 0.84 | HTR2C (0.64) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL7493732 | 0.83 | HTR2C (0.64) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL25882779 | 0.82 | HTR2C (0.68) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL4935456 | 0.82 | HTR2C (0.61) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL8890016 | 0.79 | HTR2A (0.61) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL8888059 | 0.79 | HTR2A (0.61) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL905999 | 0.79 | HTR2C (1.00) | HTR2CHTR2AHTR2BHTR1ALMNA | |
| SCHEMBL6328136 | 0.79 | HTR2C (1.00) | HTR2CHTR2AHTR2BHTR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736028-A1 | INDOLINE DERIVATIVES, METHOD OF PREPARATION AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LIMITED (GB) | 1996-10-09 | — | — | EP | claimed |
| WO-1995017405-A1 | INDOLINE DERIVATIVES, METHOD OF PREPARATION AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LIMITED (GB) | 1995-06-29 | — | — | WO | claimed |
| US-5633276-A | MELATONIN SYSTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |