Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15672960 | 0.85 | HTT (0.46) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5907933 | 0.84 | PGR (0.47) | LMNAHTTMAPTSMN1; SMN2KMT2A | |
| SCHEMBL400891 | 0.84 | CA12 (0.43) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7754750 | 0.76 | PGR (0.48) | LMNAHTTMAPTSMN1; SMN2KMT2A | |
| SCHEMBL15672929 | 0.76 | CA12 (0.48) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL12251459 | 0.76 | CA12 (0.48) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL29012544 | 0.74 | PGR (0.47) | LMNAHTTMAPTSMN1; SMN2KMT2A | |
| SCHEMBL20867846 | 0.74 | PGR (0.47) | LMNAHTTMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5907958 | 0.74 | PGR (0.45) | HTTMAPTPGRADRA2AADRA2B | |
| SCHEMBL15672824 | 0.74 | TSHR (0.46) | LMNAHTTMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | claimed |
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |