Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLI1 | P08151 | 1/20 | 0.52 |
| ▸ | GLI2 | P10070 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332320 | 0.86 | GLI1 (0.53) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL27568086 | 0.86 | PTGS1 (0.49) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL7154919 | 0.86 | PTGS1 (0.49) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL6320504 | 0.81 | CXCR1 (0.53) | PTGS2TRPV1LMNASMN1; SMN2CA1 | |
| SCHEMBL6329742 | 0.80 | PTGS1 (0.56) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL27550082 | 0.80 | PTGS1 (0.56) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL15486227 | 0.80 | PTGS1 (0.62) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL12608944 | 0.77 | GLI1 (0.64) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL27705424 | 0.75 | GLI1 (0.44) | GLI1GLI2PTGS1PTGS2TRPV1 | |
| SCHEMBL11533548 | 0.74 | GLI1 (0.81) | GLI1GLI2PTGS1PTGS2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887903-B1 | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them | DOMPE S.P.A. (IT) | 2005-05-03 | — | — | US | disclosed |
| US-6881755-B2 | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them | Dompé S.p.A. (IT) | 2005-04-19 | — | — | US | disclosed |
| EP-1123276-B1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE SPA (IT) | 2003-01-08 | — | — | EP | disclosed |