Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5714161 | 0.81 | ESR1 (0.30) | — | |
| SCHEMBL5713797 | 0.80 | ALDH1A1 (0.33) | LMNAALDH1A1TSHRKMT2AHRH3 | |
| SCHEMBL5714333 | 0.75 | NR1H3 (0.36) | ALDH1A1KMT2AHRH3KDM4ESMN1; SMN2 | |
| SCHEMBL6328486 | 0.74 | ALDH1A1 (0.33) | LMNAALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL5713665 | 0.70 | NOTUM (0.46) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL16473875 | 0.64 | TRPV1 (0.44) | ALDH1A1KMT2AHRH3TRPV1 | |
| SCHEMBL17083369 | 0.62 | SMN1; SMN2 (0.54) | LMNAALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL19154878 | 0.62 | TRPV1 (0.45) | ALDH1A1KMT2AHRH3TRPV1 | |
| SCHEMBL9164445 | 0.61 | ALDH1A1 (0.38) | LMNAALDH1A1TSHRKMT2AHRH3 | |
| SCHEMBL24123617 | 0.61 | MAPT (0.45) | LMNAALDH1A1TSHRKMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239832-A1 | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | claimed |
| US-20050239832-A1 | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239832-A1 | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors | APP, DNPEP, BACE1 | LMNA 294/4885ALDH1A1 2677/4885TSHR 4811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.